Study

Large-scale eradication of rabies using recombinant vaccinia-rabies vaccine

  • Published source details Brochier B., Kieny M.P., Costy F., Coppens P., Bauduin B., Lecocq J.P., Languet B., Chappuis G., Desmettre P., Afiademanyo K., Libois R. & Pastoret P.-. (1991) Large-scale eradication of rabies using recombinant vaccinia-rabies vaccine. Nature, 354, 520–522

Actions

This study is summarised as evidence for the following.

Action Category

Use vaccination programme

Action Link
Terrestrial Mammal Conservation
  1. Use vaccination programme

    A study in 1989–1991 in a rural region of Luxembourg, southern Belgium (Brochier et al. 1991) found that vaccinating red foxes Vulpes vulpes against rabies reduced the occurrence of rabies. After one vaccination attempt, six out of nine (67%) rabid and 11 of 14 (79%) healthy foxes tested had consumed the bait. After the second attempt, 25 of 31 (81%) adult foxes and 27 of 55 (49%) juvenile foxes tested had consumed bait, and all 86 were healthy. After the third vaccination phase, 64 of 79 (81%) foxes had consumed bait and only one tested positive for rabies (authors note that it was found at the edge of the vaccination area, and had not taken bait). Additionally, the number of cases of rabies reported in livestock every six months fell from 7–61 before the second vaccination attempt (January 1985–June 1990) to zero in the year afterwards (reporting of rabies in livestock is mandatory in Belgium). In November 1989, April 1990 and October 1990, a total of 25,000 field vaccine-baits containing VVTGgRAB and a tetracycline biomarker were dropped by helicopter across a 2,200 km2 area at a density of 15/km (excluding urban areas). After each vaccination period (January–March 1990, April–October 1990, November 1990–April 1991) a total of 188 foxes which were found dead or shot by hunters were tested for both rabies and the presence of tetracycline (which would indicate that they had consumed the bait).

    (Summarised by: Andrew Bladon)

Output references

What Works in Conservation

What Works in Conservation provides expert assessments of the effectiveness of actions, based on summarised evidence, in synopses. Subjects covered so far include amphibians, birds, terrestrial mammals, forests, peatland and control of freshwater invasive species. More are in progress.

More about What Works in Conservation

Download free PDF or purchase
The Conservation Evidence Journal

The Conservation Evidence Journal

An online, free to publish in, open-access journal publishing results from research and projects that test the effectiveness of conservation actions.

Read the latest volume: Volume 18

Go to the CE Journal

Discover more on our blog

Our blog contains the latest news and updates from the Conservation Evidence team, the Conservation Evidence Journal, and our global partners in evidence-based conservation.


Who uses Conservation Evidence?

Meet some of the evidence champions

Endangered Landscape Programme Red List Champion - Arc Kent Wildlife Trust The Rufford Foundation Save the Frogs - Ghana Bern wood Supporting Conservation Leaders National Biodiversity Network Sustainability Dashboard Frog Life The international journey of Conservation - Oryx British trust for ornithology Cool Farm Alliance UNEP AWFA Butterfly Conservation People trust for endangered species Vincet Wildlife Trust