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Providing evidence to improve practice

Individual study: Treatment with itraconazole cured a captive collection of frogs, axolotls and Kaup’s caecilians of chytridiomycosis

Published source details

Forzán M., Gunn H. & Scott P. (2008) Chytridiomycosis in an aquarium collection of frogs: diagnosis, treatment, and control. Journal of Zoo and Wildlife Medicine, 39, 406–411

This study is summarised as evidence for the intervention(s) shown on the right. The icon shows which synopsis it is relevant to.

Use antifungal treatment to reduce chytridiomycosis infection Amphibian Conservation

A before-and-after study of an established collection of amphibians in Cheshire, UK (Forzán, Gunn & Scott 2008) found that frogs, axolotls Ambystoma mexicanum and Kaup’s caecilians Potymotyphlus kaupii treated with itraconazole were cured of chytridiomycosis. Approximately 20 individuals had died before treatment (following introduction of new individuals), but once treated there were no further cases of chytridiomycosis for 60 days. The collection was therefore considered disease free. Amphibians were kept in clear plastic boxes at 19–23°C in quarantine (with strict sterilization protocols). Frogs (mainly poison frogs Dendrobates, Epipedobates and Phyllobates spp.) were bathed or soaked daily in itraconazole (10 mg/ml) for five minutes over 11 days. Axolotls and caecilians were treated with itraconazole directly in their tank water (concentration 0.01%) for 30 minutes every five days for four treatments. Following treatment, itraconazole was removed from tanks by filtering.