Study

Clinical trials with itraconazole as a treatment for chytrid fungal infections in amphibians

  • Published source details Brannelly L.A., Richards-Zawacki C.L. & Pessier A.P. (2012) Clinical trials with itraconazole as a treatment for chytrid fungal infections in amphibians. Diseases of Aquatic Organisms, 101, 95-104

Actions

This study is summarised as evidence for the following.

Action Category

Use antifungal treatment to reduce chytridiomycosis infection

Action Link
Amphibian Conservation
  1. Use antifungal treatment to reduce chytridiomycosis infection

    A randomized, replicated, controlled study in 2011 of captive amphibians in the USA (Brannelly, Richards-Zawacki & Pessier 2012) found that Australian green tree frogs Litoria caerulea and coastal-plain toads Incilius nebulifer treated with itraconazole were cured of chytridiomycosis. Itraconazole at 0.01, 0.005 and 0.003 but not 0.001% cured infection. Survival was highest with 0.003% itraconazole. However, itraconazole caused death, loss of appetite, lethargy and skin discolouration, particularly at 0.01 and 0.005%. Survival did not differ between infected animals treated for six or 11 days with 0.003% or six days with 0.005% itraconazole and untreated animals. However, treatment with all other concentrations for 11 days resulted in reduced survival (0.01%: 66–100% mortality) compared to infected untreated animals. Nine separately housed green froglets and 9–17 communally housed toadlets were randomly assigned to each treatment: infection with chytrid, infection and itraconazole baths for 5 minutes for six or 11 days and an uninfected control. Skin swabs were taken for four weeks after treatment.

     

Output references

What Works in Conservation

What Works in Conservation provides expert assessments of the effectiveness of actions, based on summarised evidence, in synopses. Subjects covered so far include amphibians, birds, terrestrial mammals, forests, peatland and control of freshwater invasive species. More are in progress.

More about What Works in Conservation

Download free PDF or purchase
The Conservation Evidence Journal

The Conservation Evidence Journal

An online, free to publish in, open-access journal publishing results from research and projects that test the effectiveness of conservation actions.

Read the latest volume: Volume 17

Go to the CE Journal

Subscribe to our newsletter

Please add your details if you are interested in receiving updates from the Conservation Evidence team about new papers, synopses and opportunities.

Who uses Conservation Evidence?

Meet some of the evidence champions

Endangered Landscape Programme Red List Champion - Arc Kent Wildlife Trust The Rufford Foundation Save the Frogs - Ghana Bern wood Supporting Conservation Leaders National Biodiversity Network Sustainability Dashboard Frog Life The international journey of Conservation - Oryx British trust for ornithology Cool Farm Alliance UNEP AWFA Butterfly Conservation People trust for endangered species Vincet Wildlife Trust