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Providing evidence to improve practice

Individual study: Treatment of chytridiomycosis requires urgent clinical trials

Published source details

Berger L., Speare R., Pessier A., Voyles J. & Skerratt L.F. (2010) Treatment of chytridiomycosis requires urgent clinical trials. Diseases of Aquatic Organisms, 92, 165-174


This study is summarised as evidence for the intervention(s) shown on the right. The icon shows which synopsis it is relevant to.

Use antifungal treatment to reduce chytridiomycosis infection Amphibian Conservation

A review in 2010 describing a replicated controlled study (Berger et al. 2010) found that treatment with benzalkonium chloride, fluconazole or methylene blue did not cure great barred frog Mixophyes fasciolatus tadpoles of chytridiomycosis. Although they did not cure infections, benzalkonium chloride and fluconazole reduced infection levels. However, at concentrations above 1 mg/L (2–10 mg/L) benzalkonium chloride caused death of tadpoles (over 29%). Methylene blue at concentrations of 12–24 mg/L also caused high mortality. Fifty-six tadpoles were bathed daily in benzalkonium chloride (1 mg/L; 3 hrs) for three days, repeated five days later, or in fluconazole (7 mg/L; 6 hrs) for seven days, or methylene blue (3 or 6 mg/L) for three days. There were 57 controls. Frogs were tested 18 days after treatment. Other studies included in this review have been summarized individually.