Protective effects of a DNA vaccine expressing the infectious salmon anemia virus hemagglutinin-esterase in Atlantic salmon
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Published source details
Mikalsen A.B., Sindre H., Torgersen J. & Rimstad E. (2005) Protective effects of a DNA vaccine expressing the infectious salmon anemia virus hemagglutinin-esterase in Atlantic salmon. Vaccine, 23, 4895-905.
Published source details Mikalsen A.B., Sindre H., Torgersen J. & Rimstad E. (2005) Protective effects of a DNA vaccine expressing the infectious salmon anemia virus hemagglutinin-esterase in Atlantic salmon. Vaccine, 23, 4895-905.
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This study is summarised as evidence for the following.
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Use vaccinations
In 2005, a replicated, controlled study in Norway (Mikalsen et al., 2005) found that the pEGFP-HE vaccine increased survival in salmon, Salmo salar, exposed to infectious salmon anaemia virus. Mortality levels in groups given the vaccine were lower than the unvaccinated control groups (16.3% and 25% versus 45% and 41.3%, respectively). Fingerling salmon were injected with a dose of a DNA vaccine expressing the virus. Dosage was repeated after week three and six. Three weeks after the final immunisation, salmon were exposed to infectious salmon anaemia virus and mortality levels were recorded for 54 days.
